What it is
Semax is a synthetic peptide analog of an ACTH fragment (ACTH 4-10). Selank is a synthetic analog of tuftsin, an immune-related peptide.
What the research says
- A rat study reported that Semax regulated BDNF and trkB expression in the hippocampus [1].
- A cell-based study reported that Selank affected expression of genes involved in GABA signaling [2].
- We did not find large randomized trials of either compound meeting U.S. standards.
Regulatory status
Semax and Selank are research-stage in the U.S. Neither is FDA approved, and compounded versions are not FDA approved. Where prescribed, compounded versions are prepared by state-licensed 503A compounding pharmacies.
Safety and side effects
The published work we cited is in rats and cultured cells, so side effects in people are unknown, and we found no large human safety studies. A licensed healthcare provider should review your history and medications first.
Is it right for you?
Only a licensed healthcare provider can decide whether any treatment is appropriate for you.
Frequently asked questions
What kind of research exists on Semax and Selank?
The published work cited here is in rats and cultured cells [1][2]. We did not find large randomized human trials.
Is Semax or Selank approved by FDA?
No. Neither Semax nor Selank is FDA approved. Compounded versions are not FDA approved.
Do I need a prescription for Semax / Selank?
Yes. Prescription only, requires evaluation by a licensed provider. A provider decides whether it is appropriate for you.
Sources
- Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res, 2006. https://pubmed.ncbi.nlm.nih.gov/16996037/
- Filatova E, et al. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Front Pharmacol, 2017. https://pubmed.ncbi.nlm.nih.gov/28293190/
Semax / Selank content on this page is for education. Compounded medications are not FDA approved. Prescription only, requires evaluation by a licensed provider. Educational content only, not medical advice.