What it is
Kisspeptin is a naturally occurring peptide hormone that acts in the brain on the pathway controlling reproductive hormone release.
What the research says
- A review described kisspeptin's role in the reproductive hormone axis [1].
- A human study reported that kisspeptin-10 raised reproductive hormone levels, with differences between men and women [2].
- A 2025 human study reported that kisspeptin administration stimulated reproductive hormones without affecting anxiety measures [3].
Regulatory status
Kisspeptin is research-stage. It is not FDA approved for any use, and compounded versions are not FDA approved. Where prescribed, compounded versions are prepared by state-licensed 503A compounding pharmacies.
Safety and side effects
FDA's compounding safety page lists kisspeptin-10. It notes possible immunogenicity and peptide-impurity risks for certain routes, and says FDA has no, or only limited, safety-related information for the proposed routes of administration [4]. Because kisspeptin acts on hormone pathways, a licensed healthcare provider should review your history, medications and relevant labs first.
Is it right for you?
Only a licensed healthcare provider can decide whether any treatment is appropriate for you.
Frequently asked questions
What has kisspeptin been studied for?
Its effect on reproductive hormone release in research settings [1][2][3]. This page makes no claim about any health condition.
Is kisspeptin approved by FDA?
No. Kisspeptin is not FDA approved and is research-stage. Compounded versions are not FDA approved.
Do I need a prescription for Kisspeptin?
Yes. Prescription only, requires evaluation by a licensed provider. A provider decides whether it is appropriate for you.
Sources
- Clarke H, et al. Endocrinol Metab (Seoul), 2015 (review). https://pmc.ncbi.nlm.nih.gov/articles/PMC4508256/
- Jayasena CN, et al. The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. J Clin Endocrinol Metab, 2011. https://pmc.ncbi.nlm.nih.gov/articles/PMC3232613/
- Mills EG, et al. Kisspeptin administration stimulates reproductive hormones but does not affect anxiety in humans. J Clin Endocrinol Metab, 2025. https://pubmed.ncbi.nlm.nih.gov/40036336
- FDA: Certain bulk drug substances for use in compounding that may present significant safety risks. https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks
Kisspeptin content on this page is for education. Compounded medications are not FDA approved. Prescription only, requires evaluation by a licensed provider. Educational content only, not medical advice.