What it is
GHK-Cu is a naturally occurring tripeptide (glycyl-histidyl-lysine) that binds copper. It has been studied in skin and wound-repair research.
What the research says
- A review described laboratory evidence that GHK influences gene activity and cellular pathways related to skin regeneration [1].
- A second review discussed regenerative and protective actions of GHK-Cu using new gene-expression data [2].
- Much of the evidence involves topical use and laboratory work.
Regulatory status
Compounded topical GHK-Cu is not FDA approved. FDA has not reviewed it for safety, effectiveness or quality. Where prescribed, compounded versions are prepared by state-licensed 503A compounding pharmacies.
Safety and side effects
Both reviews cited come from the same research group, so independent evidence is limited [1][2]. A licensed healthcare provider should review your history, medications and goals, including any copper-related conditions.
Is it right for you?
Only a licensed healthcare provider can decide whether any treatment is appropriate for you.
Frequently asked questions
What has GHK-Cu been studied for?
Mainly skin and tissue-remodeling research [1][2]. This page makes no claim about any health condition.
Is GHK-Cu approved by FDA?
No. Compounded topical GHK-Cu is not FDA approved.
Do I need a prescription for GHK-Cu?
Yes. Prescription only, requires evaluation by a licensed provider. A provider decides whether it is appropriate for you.
Sources
- Pickart L, et al. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. Biomed Res Int, 2015. https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. Int J Mol Sci, 2018. https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/
GHK-Cu content on this page is for education. Compounded medications are not FDA approved. Prescription only, requires evaluation by a licensed provider. Educational content only, not medical advice.