What it is
Delta sleep-inducing peptide (DSIP) is a small peptide first isolated from rabbit brain. It has been studied for its relationship to sleep regulation.
What the research says
- Small human studies from 1981 and 1992 examined DSIP's effects on sleep measures [1][2].
- A review described DSIP's role as 'a still unresolved riddle', meaning its physiological function is not settled [3].
Regulatory status
DSIP is research-stage. It is not FDA approved for any use, and compounded versions are not FDA approved. Where prescribed, compounded versions are prepared by state-licensed 503A compounding pharmacies.
Safety and side effects
Study sizes were small, and DSIP's mechanism is not settled [3]. The sources cited here do not establish its safety. A licensed healthcare provider should review your history and medications first.
Is it right for you?
Only a licensed healthcare provider can decide whether any treatment is appropriate for you.
Frequently asked questions
What do studies on DSIP show?
Small human studies measured sleep parameters [1][2], but DSIP's physiological function is not settled [3]. It is not FDA approved for any use.
Is DSIP approved by FDA?
No. DSIP is not FDA approved and is research-stage. Compounded versions are not FDA approved.
Do I need a prescription for DSIP?
Yes. Prescription only, requires evaluation by a licensed provider. A provider decides whether it is appropriate for you.
Sources
- Bes F, et al. Neuropsychobiology, 1992 (double-blind study; PubMed 1299794). https://pubmed.ncbi.nlm.nih.gov/1299794/
- Schneider-Helmert D, et al. Experientia, 1981 (PubMed 7028502). https://pubmed.ncbi.nlm.nih.gov/7028502/
- Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem, 2006 (PubMed 16539679). https://pubmed.ncbi.nlm.nih.gov/16539679/
DSIP content on this page is for education. Compounded medications are not FDA approved. Prescription only, requires evaluation by a licensed provider. Educational content only, not medical advice.