What it is
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule, not a peptide. It was designed to block nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism.
What the research says
- In mouse studies, selective NNMT inhibitors, including 5-amino-1MQ, were reported to alter metabolic measures in fat tissue [1].
- A later mouse study combined NNMT inhibition with a reduced-calorie diet and reported changes in gut microbiome composition [2].
- The published work we reviewed is from cell and animal studies. We did not find completed human clinical trials.
Regulatory status
5-Amino-1MQ is research-stage. It is not FDA approved for any use, and compounded versions are not FDA approved. Where prescribed, compounded versions are prepared by state-licensed 503A compounding pharmacies.
Safety and side effects
We did not find human safety data for 5-Amino-1MQ. The published studies are in cells and mice, so its side effects in people are unknown. A licensed healthcare provider should review your history and medications before deciding whether anything is appropriate.
Is it right for you?
Only a licensed healthcare provider can decide whether any treatment is appropriate for you.
Frequently asked questions
What does the research on 5-Amino-1MQ show?
Published work is mostly in cells and mice, where NNMT inhibition was associated with metabolic changes in fat tissue [1]. Animal results do not show the same effect occurs in people.
Is 5-Amino-1MQ approved by FDA?
No. 5-Amino-1MQ is not FDA approved for any use and is research-stage. Compounded versions are not FDA approved.
Do I need a prescription for 5-Amino-1MQ?
Yes. Prescription only, requires evaluation by a licensed provider. A provider decides whether it is appropriate for you.
Sources
- Neelakantan H, et al. Biochem Pharmacol, 2018 (mouse study). https://pmc.ncbi.nlm.nih.gov/articles/PMC5826726/
- Sci Rep, 2021 (mouse study). https://www.nature.com/articles/s41598-021-03670-5
5-Amino-1MQ content on this page is for education. Compounded medications are not FDA approved. Prescription only, requires evaluation by a licensed provider. Educational content only, not medical advice.