MOTS-C is a mitochondrial-derived peptide studied for metabolic regulation, insulin sensitivity, and longevity signaling. Physician-reviewed. Prescription required.
MOTS-C is a mitochondrial-derived peptide studied for metabolic regulation, insulin sensitivity, exercise mimicry, energy expenditure, and longevity signaling. It acts via AMPK pathway activation to support healthy cellular metabolism and aging biology.
MOTS-C (Mitochondrial-Open Reading Frame of the Twelve S rRNA type-C) is a peptide derived from mitochondrial DNA. Unlike traditional peptide hormones produced by glands, MOTS-C is generated within the mitochondria itself, making it a key regulator of cellular energy metabolism and mitochondrial function.
MOTS-C has been extensively studied for its role in regulating systemic metabolism. It acts as a circulating peptide that influences whole-body energy homeostasis, glucose metabolism, insulin sensitivity, and the oxidative capacity of skeletal muscle. Research suggests MOTS-C may promote metabolic health at the cellular and systemic levels.
By modulating AMPK (AMP-activated protein kinase) signaling, MOTS-C supports the body's natural metabolic processes, enhances mitochondrial biogenesis, and may contribute to healthy aging and longevity pathways.
AMPK Pathway Activation: MOTS-C activates AMPK, a master metabolic sensor that regulates energy metabolism throughout the body. AMPK activation increases NAD+ levels, supports mitochondrial biogenesis, and enhances cellular energy utilization.
Glucose Homeostasis: By activating AMPK, MOTS-C promotes glucose uptake in muscles and improves insulin sensitivity. This supports healthy blood sugar regulation and may reduce metabolic dysfunction associated with obesity and insulin resistance.
Exercise Mimicry: MOTS-C produces metabolic effects similar to exercise, including increased fatty acid oxidation, enhanced mitochondrial function, and improved physical performance capacity. This makes it particularly relevant for those seeking exercise-like metabolic benefits.
Energy Expenditure: MOTS-C increases cellular energy expenditure by promoting mitochondrial oxidative metabolism. This supports weight management and metabolic efficiency.
Longevity Signaling: MOTS-C activates pathways associated with healthy aging, including sirtuins and mTOR regulation. Preclinical data suggests MOTS-C may extend healthspan and support longevity through mitochondrial optimization.
Not a candidate? During your physician consultation, your medical history, current medications, metabolic status, and health goals will be evaluated. MOTS-C may not be appropriate if you have certain metabolic conditions or other contraindications. Your physician will determine suitability.
MOTS-C is not FDA-approved as a finished drug product. It is dispensed as a compounded medication through licensed 503A compounding pharmacies. A valid physician prescription is required before any order can be filled. All Verum Health protocols require a clinical consultation and physician approval.
MOTS-C is typically administered as a subcutaneous injection. Standard dosing is 2MG/ML or 10MG/ML concentrations (5ML vials). Exact dosing and injection frequency will be determined during your physician consultation based on your individual needs, metabolic status, and treatment goals. Common dosing protocols range from 2-6 mg per dose, 2-5 times per week.
Follow-up assessments may include metabolic labs (glucose, insulin, lipid panel) and body composition analysis to evaluate response. Your physician will schedule check-ins to assess efficacy, tolerability, and adjust dosing as needed. Reorders require physician approval based on lab results and clinical outcomes.