5-Amino-1MQ is an NNMT inhibitor studied for NAD+ preservation, fat metabolism, mitochondrial function, and metabolic longevity. Physician-reviewed. Prescription required.
5-Amino-1MQ is a small-molecule research compound known primarily as a selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It has been studied in preclinical models for effects on cellular energy metabolism, NAD+ biology, and adipocyte function.
This indirect NAD+ preservation mechanism supports sirtuin activity, mitochondrial function, and adipose tissue metabolism. 5-Amino-1MQ also preserves the SAM (S-adenosylmethionine) methyl donor pool, with downstream epigenetic implications. Individual outcomes may differ. This protocol is not intended to diagnose, treat, cure, or prevent any disease.
| Mechanism | Biological Effect |
|---|---|
| NNMT inhibition | Preserves nicotinamide, supports NAD+ |
| Increased NAD⁺ synthesis | Enhanced cellular energy, sirtuin activity |
| SAM preservation | Maintains methyl donor pool |
| Adipose metabolic regulation | Increased fat oxidation, reduced storage |
| Indirect activation of NAD⁺-dependent enzymes | Improved mitochondrial function |
Your physician will determine eligibility based on your complete health intake. The following profiles are commonly associated with 5-Amino-1MQ protocol candidates in clinical practice:
NAD+ Optimization
Individuals seeking physician-supervised NAD+ pathway support without direct NAD+ supplementation.
Fat Metabolism
Individuals pursuing physician-reviewed adipose tissue metabolic activation.
Longevity Protocol
Individuals with established longevity protocols adding physician-reviewed NNMT inhibition support.
Combination Protocol
Patients combining 5-Amino-1MQ with NAD+ or other metabolic compounds under physician oversight.
Determine your candidacy
A physician will review your intake and make eligibility determination within 24–48 hours.
All outcome language below reflects what has been observed in clinical and preclinical settings. Individual outcomes may differ significantly. These are not guarantees.
Dosing is determined individually by your assigned physician. The following represents typical ranges discussed in clinical literature. Do not self-administer or adjust dosing without physician guidance.
Typical Range
Physician-determined
Administration
Oral
Duration
Physician-determined cycles
Frequency
Daily (physician-determined)
These ranges are indicative only. Your physician will prescribe the specific dose and schedule appropriate for your clinical profile.
Physician consultation — Virtual intake review and protocol consultation with your assigned NP/MD
Valid prescription — Issued by your attending physician upon protocol approval
Pharmacy-dispensed compound — Dispensed by our licensed 503A compounding pharmacy partner
Follow-up check-in — Physician review at protocol midpoint; reorder pathway established
Your physician will review your complete health history before determining eligibility. The following are commonly reviewed clinical considerations.
Begin your 5-Amino-1MQ protocol.
Complete your intake. Physician review within 24–48 hours.
Physician-reviewed. Pharmacy-dispensed. Prescription required before any order is fulfilled.
Prescription required. Results may vary. Individual outcomes may differ.
5-Amino-1MQ inhibits the NNMT enzyme, which plays a key role in fat cell metabolism. It is used for fat loss, metabolic optimization, and as a complement to GLP-1 or growth hormone protocols.
By inhibiting NNMT (nicotinamide N-methyltransferase), 5-Amino-1MQ prevents the inactivation of NAD+ inside fat cells, restoring their ability to burn energy rather than store it.
Yes. 5-Amino-1MQ is frequently stacked with semaglutide or tirzepatide for enhanced fat loss, particularly for visceral and stubborn adipose tissue. Your Verum Health physician can design a combined protocol.
5-Amino-1MQ is available in capsule form at Verum Health — one of the few metabolic peptides available orally, making it easy to add to any existing protocol.